Web Reference: Mar 2, 2026 · Aging results from several factors, including genetics, our environment, and cellular damage. Genetic components, such as telomeres, influence lifespan. Oxidative stress and lifestyle choices also play key roles. Aging, arguably the most complex human phenotype, is the combined effect of all processes in an organism that leads to a probabilistic increase in the occurrence of disease and eventually death. The characteristics of aging are its complexity and its late‐life multimorbidity. Fig 1: Chromosomes (grey) shown with their telomeres (white dots) at the end. Telomere shortening is one well-known factor that leads to our cells losing the ability to divide. Our DNA is stored as tightly wrapped strands which form structures called chromosomes. Telomeres are located at the very end of chromosomes, seen as bright dots in the image...
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