Web Reference: We present Envision, an accurate predictor of protein variant molecular effect, trained using large-scale experimental mutagenesis data. All data and software in this study are freely available. Decima’s Variant Effect Prediction (VEP) module allows you to predict the effects of genetic variants on gene expression. This tutorial demonstrates how to use the VEP functionality through both command-line interface (CLI) and Python API. Using variant effect prediction within python allows more flexibility in the finegrain details compared to using the command line interface. The core function of variant effect prediction is score_variants, which on the one hand requires a model with its dataloader as well as a valid VCF.
YouTube Excerpt: In this video, we walk through the code for using the ESM-2 protein language model to
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