Web Reference: The original source for this information is the AJCC Cancer Staging System (2020). The CAP developed these protocols as an educational tool to assist pathologists in the useful reporting of relevant information. After you review this material, you can watch the lecture on tumor staging and grading or test your knowledge with this free tumor staging and grading quiz. To grade a tumor a biopsy is done. Cancer genomics is a rapidly evolving field; therefore, the clinical significance of any variant in therapy, diagnosis, or prognosis should be reevaluated on an ongoing basis. Reporting of genomic variants should follow standard nomenclature, with testing method and limitations clearly described.
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Last Updated: April 2, 2026

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