Web Reference: Learn about solid-phase extraction (SPE), a technique to separate, isolate or purify compounds from a liquid mixture. Find out how SPE works, what types of stationary phases are used, and how to perform SPE steps. Solid phase extraction1 (SPE) is a sample preparation technique using a solid adsorbent contained most commonly in a cartridge device (Figure 1), or on a disk to adsorb select species from solution. Solid-phase extraction (SPE) is an effective way to prepare samples in chemistry. A sample collection and analysis gap can be closed using SPE as one of the methods.
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