Web Reference: How to solve genetics problems that involved multiple genes in a genotype. This examples shows genotypes with 4 genes. This project was created with Explain ... Researchers are learning that nearly all conditions and diseases have a genetic component. Some disorders, such as sickle cell disease and cystic fibrosis, are caused by variants (also known as mutations) in single genes. The causes of many other disorders, however, are much more complex. Common health problems such as heart disease, type 2 diabetes, and obesity do not have a single genetic cause—they are influenced by multiple genes (polygenic) in combination with lifestyle and environmental factors, such as exercise, diet, or pollutant exposures. Conditions caused by many contributing factors are called complex or multifactorial disorders. A “complex genetic disease” is defined as a multifactorial genetic disorder resulting from multiple genetic variants on several genes (ie, polygenic) with contributions from environment and lifestyle.
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